Attention Deficit Hyperactivity Disorder

 

Symptoms must be present prior to age 7, last longer than 6 months, and impair functioning to receive the diagnosis. For children, this generally means difficulty achieving or maintaining appropriate behavior in school. Boys are often referred at an earlier age due to hyperactivity; Girls are often “silent sufferers” because they have less hyperactivity or impulsivity and go unrecognized. Must consider developmental levels in making the diagnosis (e.g., differentiating normal activity levels). It was once felt that all children  outgrow ADHD by adolescence, however we now know that approximately 50% continue to evidence symptoms into adulthood.

 

 

 

 

Attentional Sypmtoms

 

¨     Difficulty sustaining attention

¨     Easily distracted

¨     Careless or sloppy schoolwork

¨     Difficulty following directions or multiple instructions

¨     Fails to finish work or follow through on chores

¨     Difficulty organizing tasks and activities

¨     Frequently loses things or is forgetful

 

 

 
Hyperactivity Symptoms

 

¨     Fidgets or squirms

¨     Difficulty remaining in seat

¨     Runs about or climbs excessively

¨     Difficulty playing quietly

¨     Always “on the go”

¨     Talks excessively

 

 

 

 

 

 

 

Medications Commonly Used To Treat Attention Deficit Hyperactivity Disorder

 

 

Psychostimulant Medications

 

 

Short Acting                                                       Long Acting

 

Ritalin                                                                                      Ritalin LA

Dexedrine                                                                                 Concerta

Adderall                                                                                   Metadate

Cylert                                                                                       Dexedrine Spansule

Focalin                                                                                     Adderall XR

 

                                                                                               

 

Mechanisms of Action

 

¨     Short acting forms begin working in 20 minutes and last 3 – 4 hours. Short acting forms are used when appetite and weight gain are an issue They have the added stigma of children having to leave class to take the medication, they have to be dosed multiple times a day, and symptoms of ADHD increase as medications are wearing off and prior to the next dose (e.g. kids are often under-medicated during the last class before lunch, cafeteria time, and last class of the day).

¨     Long acting forms begin working in 20 minutes and last throughout school and homework time/afterschool program (8 – 12 hours). They are gradually released over time and you avoid the peaks and lows. The downside is that kids will have a very poor appetite for the entire time that the medication is in their system.

 

Side Effects

 

¨     Appetite suppression

¨     Growth suppression

¨     Increased Blood Pressure

¨     Rebound irritability: occurs when the medication is wearing off. More likely to occur with short acting forms; Includes crying, irritability, personality changes, and clingy behavior.

¨     Tics: may be “unmasked” in children who are at risk.

¨     Headaches: usually only within the first week, responds to aspirin.

¨     Stomachache: if taken on an empty stomach.

¨     Cylert may cause fatal liver problems

 

 

Other First Line Medications Used to Treat ADHD

 

 

Straterra

 

¨     Antidepressant class of medication

¨     Takes 4-6 weeks to gain maximum effectiveness

¨     Requires daily intake for effectiveness

¨     Reduced rate of appetite suppression and other side effects

¨     May improve mood

 

 

 

Second Line Medications Used to Treat ADHD

 

Imipramine

 

¨     An antidepressant rarely used to treat depression because of the side effects if used in higher doses.  Also used to treat bedwetting.  May also be used for sleep in lower doses.

¨     Treats attentional symptoms but not hyperactivity symptoms.

¨     Less effective than stimulants, but often used when stimulants are contraindicated (eg. tics, weight loss). Effectiveness develops over 3 – 4 weeks.

¨     Side Effects: Sedation, dry mouth, low blood pressure, blurred vision, constipation, cardiac problems.

 

Wellbutrin

 

¨     Commonly used in the treatment of anxiety and depression. Effective in 3 to 4 weeks.

¨     Works better on concentration and attention span than on hyperactivity. The sustained release formula appears more effective.

¨     Marketed under a different brand name (Zyban) for smoking cessation

¨     Appears helpful in mood changes in substance abusing children

¨     Side Effects: Generally well tolerated with few side effects (stomach upset); Increased risk of seizures in those who have a seizure disorder or an eating disorder.

 

 

 

 

 

 

 

 

Clonidine

 

¨     An anti-hypertensive medication commonly used for hyperactivity and aggression. It does not work well for attentional symptoms. Also available in a patch. Effect increases over time (weeks).

¨     Side Effects: May affect heart rate and rhythm along with blood pressure; Headaches, dizziness, dry mouth, constipation, fluid retention, and nervousness.

 

 

 

Major Depression

 

      The average age of onset is in the mid-20’s, however the age has been decreasing over the past decade. The lifetime is 10-25% in females and 5-12% in males. Depression is twice as common in adolescent and adult females than males, however pre-pubertal rates are equal in boys and girls. Most episodes recover within a year but 60% of people who have experienced one episode of depression will have another episode in their lifetime. Depression affects health status with more people experiencing pain and physical illness. Up to 15% of individuals with severe depression successfully complete suicide. To receive the diagnosis 5 or more of the following symptoms must be present for at least 2 weeks, and symptoms must impair functioning.

 

 

Symptoms

 

¨     Depressed mood, nearly every day (mood can be irritable in children)

¨     Lack of interest in pleasurable activities

¨     Weight loss or appetite reduction/ weight gain or increased appetite

¨     Insomnia or hypersomnia

¨     Psychomotor agitation or retardation

¨     Fatigue or loss of energy

¨     Feelings of worthlessness or excessive guilt

¨     Difficulty concentrating

¨     Recurrent thoughts of death

 

 

 

 

Medications Commonly Used to Treat Depression

 

 

Tricyclic Antidepressants (TCA’s)

 

¨     Increases Norepinephrine (NE) levels

¨     Nortyptylline, Amitryptylline, Imipramine, Desipramine, Clomipramine, Sinequan, and Trazadone

¨     Effective in treating chronic pain syndromes and migraine headaches

¨     Rarely used in children for depression; often used for insomnia

¨     May require blood levels if used in higher doses. Can become toxic at higher levels and may cause death. Effective in 3 – 4 weeks.

¨     Side Effects: Sedation, dry mouth, orthostatic hypotension, blurred vision, constipation, cardiac problems.

 

 

Selective Serotonin Reuptake Inhibitors (SSRI’s)

 

¨     Prozac, Paxil, Zoloft, Celexa, Lexapro

¨     Safer, well-tolerated, requires no blood ministering, non-fatal in overdose

¨     Often used to treat anxiety related disorders (Panic Attacks, Phobias, Post-Traumatic Stress Disorder, Generalized Anxiety) in higher doses

¨     Effective in 4 –6 weeks

¨     Side Effects: Headaches, nausea, agitation, sexual dysfunction;

Flu-like symptoms if discontinued rapidly; Serotonergic crisis with increased temperature, blood pressure, and heart rate occurs when used in combination with similar agents, or may be dose related.

¨     Paxil recently received an FDA warning in children

 

 

“Mixed Agents”

 

¨     Increases levels of Norepinephrine and Serotonin

¨     May take 3-4 weeks for effectiveness to develop

¨     Generally well tolerated with few side effects (similar to SSRI’s).

¨     Serzone: relatively new; Black Box Warning for liver abnormalities

¨     Effexor: may lead to increased blood pressure

¨     Remeron: Sedating, used for sleep a lot, available in a dissolving tab

 

 

 

Wellbutrin

 

¨     See above information under ADHD

 

 

MonoAmine Oxidase Inhibitors

 

¨     Parnate, Nardil, Marplan

¨     Increases levels of  Norepinephrine, Serotonin, and Epinephrine

¨     May cause a fatal hypertensive crisis if used with other antidepressants and anxiolytics, or foods that contain tyramine

¨     Requires strict dietary requirements and therefore used only in treatment resistant depression

 

 

Bipolar Disorder

 

            The lifetime prevalence of Bipolar Disorder is 0.4 to 1.6%. Average age of onset is 20. Disorder is equally common in men and women, though the first episode is more likely to be depression in women and mania in men. Individuals must have at least one episode of depression lasting at least 2 weeks and one episode of mania lasting at least a week to meet criteria. The first manic episode may emerge as a result of antidepressant treatment. Children often present as “rapid cyclers”. Approx. 95% of children with the disorder have a pre-morbid history of ADHD. There is a high co-morbidity with drugs and alcohol, and completed suicide occurs in 10-15% of cases. DSM-IV includes types I and II; DSM V may include Types I-VI.

 

Manic Symptoms

¨     Inflated self-esteem or grandiosity

¨     Decreased need for sleep

¨     Increase in goal-directed activities

¨     Excessive talking with rapid speech

¨     Racing thoughts or flight of ideas

¨     Distractibility or poor attention span

¨     Excessive involvement in pleasurable activities (e.g. buying things, hypersexuality)

¨     Mood is often irritable in children and behavior can be aggressive

¨     Engaging in high risk or dangerous activities

¨     Psychotic symptoms may be present

 

 

Dysthymia

 

¨     Chronic depressed mood that lasts for 2 or more years (1 year in children), has at least two of the symptoms in Major Depression but does not meet full criteria

¨     Prevalence rates of 6%; occurs equally in both sexes

¨     Children evidence low self-esteem, poor social skills, irritability, and pessimism

 

 

Cyclothymia

 

¨     Fluctuating mood with hypomanic and depressive symptoms for a period of at least 2 years (1 year in children)

¨     Prevalence rates of  .4% to 1%; occurs equally in both sexes

¨     15 to 50% risk of developing Bipolar Disorder

 

Intermittent Explosive Disorder

 

 

¨     Several discrete episodes of aggression that result in assault or destruction

¨     Aggressive acts are out of proportion to the precipitating stressor

 

 

 

Medications Commonly Used To Treat Bipolar Disorder, Impulse Control Disorders and Aggression

 

 

 

Lithium

 

¨     A natural salt; mechanism of action unclear. May take 1 –3 weeks to become effective.

¨     Requires frequent blood monitoring of therapeutic levels (weekly, then every 3-6 months)

¨     Therapeutic levels are affected by salt and water intake, urinary output, and sweat. Important to monitor in children.

¨      Common Side Effects: nausea, diarrhea, weight gain, headache, fine hand tremor, acne, and skin rashes

 

 

 

Depakote

        

¨     An anti-convulsant. May take 1-3 weeks to become effective.

¨     Requires monitoring of blood levels (weekly, then every 3-6 months)

¨     Side Effects: nausea, vomiting, weight gain, sedation, clumsiness, decrease in blood cells, liver damage, and polycystic ovarian disease

 

 

Tegretol

 

¨     An anti-convulsant. May take 1-3 weeks to become effective.

¨     Requires monitoring of blood levels (weekly, then every 3-6 months)

¨     Side Effects: sedation, dizziness, clumsiness, blurred or double vision, hair loss, nausea, and increased sensitivity to the sun. Serious side effects include liver and kidney damage, lung irritation, dramatic drops in blood cells, and severe skin rashes.

 

 

Trileptil

 

¨     An anti-convulsant; may take 1-3 weeks to achieve effectiveness

¨     Does not require monitoring of blood levels

¨     May cause dizziness, sedation, abdominal discomfort, fatigue, abnormal gait, and double vision

 

 

Topomax

 

¨     An anti-convulsant; may take 1-3 weeks to achieve effectiveness.

¨     Does not require monitoring of blood levels

¨     May cause nausea, tremor, fatigue, dizziness, abnormal gait, sedation, psychomotor slowing

¨     Attractive to many patients due to gradual weight loss

 

 

Neurontin

 

¨     An anti-convulsant. May take 1-3 weeks to achieve effectiveness.

¨     Does not require blood levels

¨     Relatively new and side effects not well known

¨     May cause agitation

 

 

 

Lamictal

 

¨     An anti-convulsant; may take 1-3 weeks to achieve effectiveness.

¨     Relatively new; may cause agitation and rashes; other side effects not well known.

 

 

Keppra

 

¨     An anti-convulsant; may take 1-3 weeks to achieve effectiveness.

¨     Does not require monitoring of blood levels

¨     May cause tingling sensations, dizziness, sedation, and infection

 

 

 

 

Schizophrenia

 

        

Prevalence rates of 0.5-1.5%. with a slightly higher incidence in men. First degree relatives have a 10x greater risk of developing the illness. Age of onset is between the late teens and mid-30’s. Prognosis is poor, with a decline in functioning after each psychotic episode, shortened life span, 10% successfully complete suicide, and 60-70% never marry. Factors that improve prognosis include: good pre-morbid adjustment, acute onset, later age of onset, being female, mood disturbance, medication initiation soon after onset, medication compliance, brief duration of active phase symptoms, good inter-episode functioning, absence of brain abnormality, normal neurological functioning, family history of a mood disorder, and no family history of  Schizophrenia. Symptoms must be present for at least 6 months (may include prodromal and residual phases) and impair functioning for diagnosis.

 

Symptoms

 

¨     Delusions (persecutory and referential are most common)

¨     Hallucinations (auditory most common)

¨     Disorganized Speech (loose associations, tangential, incoherent)

¨     Disorganized or catatonic behavior (childishness, poor hygiene or dress, oddities, rigidity, agitation)

¨     Negative Symptoms (flat affect, slow thought processes and speech, lack of initiation in activities)

 

 

 

Medications Commonly Used To Treat Psychosis

        

 

         Helpful in a variety of psychiatric illnesses to target symptoms of psychosis, aggression, agitation/low frustration tolerance, thought disorganization, impulsivity, and sleep disturbance.

 

Older Neuroleptics

 

 

¨     Low Potency: Thorazine and Mellaril may cause orthostatic hypotension, urinary retention, blurred vision, sedation, and constipation.

¨     Mid Potency: Stelazine, Trilafon, and Navane  may cause a mixture of side effects from high and low potency medications, usually they are less severe

¨     High Potency: Haldol and Prolixin may cause EPS symptoms: shuffling gait, stiffness in the neck, tongue, and limbs, rigidity, difficulty eating or swallowing; flat affect, dry mouth, sedation, restlessness, and a decrease in the seizure threshold

¨      Benadryl, Cogentin, or Artane are often used in conjunction with these medications to prevent side effects

 

 

Newer Neuroleptics

 

¨     Zyprexa, Risperidol, Seroquel, Geodon, and Abilify

¨     Much safer and fewer side effects than older neuroleptics.

¨     May cause weight gain, breast enlargement, breast “discharge”, and decrease the seizure threshold. Risperidol has been shown to cause EPS symptoms at higher doses.

 

 

 

 

 

 

 

 

 

 

Obsessive-Compulsive Disorder (OCD)

 

 

Prevalence rates of 1 to 2.3% in children. Childhood onset occurs more frequently and earlier in males (age 6-15) than females (age 20-29). There is a high association with Learning Disorders, Disruptive Behavior Disorders, and body concerns in children. A subset of children develop acute pre-pubertal symptoms associated with Streptococcal infections. 20-30% have a current or past history of tics. Children must engage in the symptoms for greater than one hour a day, and are not required to experience symptoms as ego-dystonic (as in adults). Symptoms are more likely to present themselves at home than in public. The course is “waxing and waning”, with symptoms remitting and changing over time.

 

 

 

Obsessions

 

¨     Recurrent, intrusive thoughts, images or impulses that are not merely everyday worries or concerns

¨     Person attempts to ignore or suppress the thoughts (ego-dystonic)

¨     Person recognizes the thoughts as a product of their own mind (not always true in children)

¨     Most common obsessions are about contamination, repeated doubts, need to have things in order, aggressive or horrific impulses, and sexual imagery

 

 

Compulsions

 

¨     Repetitive behaviors or mental acts

¨     Behaviors are aimed at reducing distressing or to avoid a dreaded event or situation

¨     Most common compulsions involve washing and cleaning, counting, checking, requesting or demanding reassurances, repeating actions, and ordering

 

 

 

 

 

 

 

 

 

 

Medications Commonly Used To Treat Obsessive-Compulsive Disorder (OCD)

 

 

Luvox

 

¨     Serotonergic agent, well tolerated, with few side effects.

¨     Marketed specifically for OCD, main effects in 4-6 weeks.

 

Clomipramine

 

¨     See above section under TCA’s.

¨     Rarely used now that other med’s are available due to side effects.

 

 

SSRI’s

 

¨     Usually require higher doses (see above section under depression)

                 

 

 

 

Generalized Anxiety Disorder

 

 

 

Formerly referred to as Overanxious Disorder of Childhood. Prevalence rate of 5%. More common in women. Children tend to be shy and inhibited, perfectionistic and overly conforming, to worry about their performance in school and sports, have excessive concerns about punctuation and often redo tasks, and seek constant reassurance. The course is generally fluctuating, worsening during periods of stress. To receive the diagnosis a person must have excessive anxiety and worry for 6 months, find it difficult to control the worry, and have at least 3 of the following associated symptoms.

 

 

 

 

 

 

 

Symptoms

 

¨     Restlessness or feeling “keyed up”

¨     Easily fatigued

¨     Difficulty concentrating or mind going blank

¨     Irritability

¨     Muscle tension

¨     Sleep disturbance

 

 

 

Social Anxiety Disorder

 

           

Lifetime prevalence rates of 3-13%. SAD accounts for 10-20% of all anxiety disorders and is more common in women than men. The avoidance, anxious anticipation, or distress must impair functioning and last for at least 6 months.

 

¨     Marked and persistent fear of one or more social or performance situations

¨     Person fears humiliation or embarrassment

¨     Must include fear of age-appropriate relationships in children

¨     Exposure to the situation causes increased anxiety or panic symptoms (may include crying, tantrums, or “freezing”

¨     Person recognizes the fear as unreasonable (not necessary in children)

¨     Feared situations are avoided

 

 

Associated Symptoms of  SAD in Children

 

¨     Fear of rejection and hypersensitivity to criticism

¨     Difficulty being assertive

¨     Low self esteem and feelings of inferiority

¨     Poor social skills

¨     Decline in academic performance or school refusal

¨     Avoidance of age appropriate social activities

¨     Crying, tantrums, freezing, clinging to familiar people

¨     May lead to mutism since children are often unable to avoid feared situations

 

 

 

 

 

 

Specific Phobia

 

 

Lifetime prevalence rates of  7.2 –11.3 %. Twice as common in women than men. Symptoms usually begin in early childhood or adolescence. Predisposing factors include exposure to traumatic events, observation of others undergoing trauma or demonstrating fear, and informational exposure. Diagnosis requires a marked and persistent fear, anxiety or panic upon exposure, recognition that the fear is unreasonable (not true in children), avoidance of feared situation, and functional impairment.

 

 

Four Subtypes

¨     Animal Type

¨     Natural Environment Type

¨     Body Injection Injury Type

¨     Situational Type

 

 

 

 

Selective Mutism

 

        

Disorder is rare, occurring in less than 1% of the population. Onset is generally before age 5. Associated symptoms include: excessive shyness, fear of social embarrassment, social isolation and withdrawal, clinging, compulsive traits, negativism, temper tantrums, and controlling and oppositional behavior

 

¨     Consistent failure to speak in specific social situations (in which there is an expectation for speaking) despite speaking in other situations

¨     Problems interfere with functioning and last for at least a month

¨     Failure to speak is not associated with lack of knowledge or comfort with language

¨     Symptoms must persist for at least a month

 

 

 

 

 

 

 

 

 

 

 

Separation Anxiety Disorder

      

 

Prevalence rate of 4% in children and young adolescents. The disorder is equally common in males and females in clinical samples, but higher in females in epidemiological studies. Onset may occur after a life stressor (e.g., move, divorce) and usually there are periods of emission and exacerbation. Associated symptoms include social withdrawal, sadness, difficulty concentrating, fearfulness, anger and aggression when separation is forced, school refusal, unusual perceptual experiences (e.g., feeling things are staring at them, hearing name called), demanding behavior, in constant need of attention, intrusiveness, and somatic complaints. Diagnosis requires onset before age 18, symptom duration of at least 4 weeks, and excessive anxiety concerning separation from home and attachment figures as evidenced by three or more of the following symptoms.

 

 

Symptoms

 

¨     Inappropriate and excessive anxiety about separation from home or attachment figures

¨     Anticipation of separation causes distress, imagines situations where separation may become possible

¨     Worries about harm or death occurring to attachment figures

¨     Refusal or reluctance to go to school, or to be at home alone

¨     Reluctance and refusal to go to sleep without attachment figure nearby

¨     Nightmares involving themes of separation

¨     Frequent physical complaints

 

 

 

 

 

 

 

 

 

 

 

Panic Disorder

 

 

Prevalence rates of 1-2%. Approx. 30-50% develop agoraphobia. Disorder is 2 to 3 times more common in women. Age of onset is usually between mid-adolescence and mid-30’s. First degree relatives are 8 times more likely to develop the disorder.  At 10 years, 30% are well, 40-50% are improved but remain symptomatic, and 20-30% have symptoms that are the same or worse. Diagnosis requires recurrent unexpected panic attacks (sudden onset of symptoms that peak within 10 minutes and is accompanied by a sense of danger or doom), persistent concern over another attack, situational avoidance, and at least 4 of the following cognitive or somatic symptoms.

 

 
Panic Attacks

 

¨     Palpitations, increased heart rate, chest pain

¨     Sweating

¨     Trembling or shaking

¨     Shortness of breath or feeling smothered

¨     Choking sensation

¨     Chest pain or discomfort

¨     Nausea or abdominal discomfort

¨     Dizziness, lightheaded, faint

¨     Derealization or depersonalization

¨     Fear of losing control or going crazy

¨     Fear of dying

¨     Numbness or tingling sensations

¨     Chills or hot flushes

 

Post-Traumatic Stress Disorder

 

           

Prevalence rate of approximately 8% of the adult population. Symptoms can occur at any age, usually within the first three months of witnessing or experiencing a trauma. Complete recovery occurs within 3 months in half of the cases. Prolonged exposure, depression in first degree relatives, and the degree of helplessness increases vulnerability.  Associated features include impaired affect modulation, self-destructive or impulsive behavior, somatic complaints, feelings of ineffectiveness, shame, despair, hopelessness, feeling permanently damaged, loss of previously sustained beliefs, hostility, social withdrawal, feeling constantly threatened, impaired relationships with others, a change from previous personality characteristics, and survival guilt. There are 4 sets of diagnostic criteria and symptoms must be present for at least 1 month for diagnosis.

           

 

 

Criteria A-Exposure

 

¨     Person must witness, experience, or be confronted with an event that involves actual or threatened death or serious injury, or a threat to the physical integrity of others

¨     Person’s response involves intense fear, helplessness, or horror

 

 

 

Criteria B-Reexperiencing

 

¨     Recurrent and intrusive recollections (may involve repetitive play)

¨     Distressing and recurrent dreams

¨     Re-experiencing the event (may include flashbacks, dissociation, hallucinations)

¨     Psychological distress at exposure to internal or external cues

¨     Physiological reaction to cues or triggers

 

 

Criteria C-Avoidance

 

¨     Attempts to avoid thoughts, feelings, conversations related to trauma

¨     Avoidance of people, places, activities that arouse memories

¨     Inability to recall an important aspect of the trauma

¨     Diminished interest or participation in significant activities

¨     Feelings of detachment or estrangement from others

¨     Restricted range of affect

 

 

Criteria D-Arousal

 

¨     Difficulty falling asleep

¨     Irritability or outbursts of anger

¨     Difficulty concentrating

¨     Hypervigilance

¨     Exaggerated startle response

 

 

 

 

 

Medications Commonly Used To Treat Anxiety Disorders

           

 

SSRI’s  (see section under depression; requires higher doses)

 

Wellbutrin (see section on ADHD).

 

Buspar

 

 

¨     May cause dizziness, nervousness, nausea, headache, restlessness, or insomnia. Effects seen in 2 – 3 weeks.

 

 

 

Benzodiazepines (also called Sedative\Hypnotics or tranquilizers)

 

 

¨     Includes Valium, Ativan, Xanax, Librium, Vistaril, and Klonopin

¨     Xanax is the most addictive, Klonopin the least addictive

¨     Medications effective within 15 – 30 minutes are addictive if taken over extended periods of time

¨     Side Effects: sedation and cognitive dulling; Uncontrollable behavior; aggression; irritability may occur in some children and should be discontinued if this happens.

 

 

 

 

 

Reactive Attachment Disorder

 

 

        

Limited data on prevalence rates. Onset of disturbed and developmentally inappropriate social relatedness must occur before age 5. Course is variable. Requires pathogenic care during the early years. There are 2 subtypes.

 

 

 

Pathogenic Care

¨     Persistent disregard of the child’s emotional needs

¨     Persistent disregard of the child’s basic physical needs

¨     Repeated changes of primary caregiver

 

 

 

 

Inhibited Type

¨     Highly ambivalent or contradictory responses to caregivers (mixture of approach and avoidant behaviors, resistance to comfort or nurturing, hypervigilance, excessively inhibited)

 

Indiscriminate Type

¨     overly attaches to anyone, overly responsive and loving with strangers, inability to exhibit selective attachments

 

 

 

 

Asperger’s Disorder

 

           

Prevalence rates are unknown. The disorder is five times more common in males than females. Mental retardation is uncommon. Verbal skills are usually much stronger than nonverbal skills. Because there is no delay in language , symptoms are often overlooked. Adult-like verbal skills often leads others to attribute symptoms to behavioral problems or stubbornness.  These children usually desire friendships but have difficulty developing them. Associated symptoms include: ADHD, depression, and motor clumsiness, pseudomaturity, and sensitivity to change.

 

 

Symptoms

 

¨     Impaired social interactions: failure to develop age appropriate peer relationships, no desire to seek or share enjoyment or interests with others, lack of social or emotional reciprocity, impairment in the use of nonverbal behaviors

 

¨     Restrictive Behavior: Repetitive, stereotyped behaviors, interests, and activities, intense focus and preoccupation with things that do not interest others, inflexible adherence to nonfunctional routines or rituals, stereotyped or repetitive mannerisms, preoccupation  with “parts” of objects.

 

 

 

 

 

 

 

 

Autism

 

        

Occurs in 5 per 10,000 individuals. Rates are five times higher in males than females. Females with the disorder are more likely to have severe mental retardation. Mental retardation occurs in over 75% of cases and ranges from mild to severe. The development of cognitive skills is uneven with weaker verbal skills. Symptoms must be present in at least one area  prior to age 3 (20% of children have normal functioning for the first 2 years). 25% of children develop seizures. A subset may develop highly specialized skills that are nonfunctional. Associated features include: ADHD, impulsivity, aggression, temper tantrums, self-injurious behavior, oversensitivity to sensory stimuli, high threshold for pain, sleeping and eating abnormalities, mood and affect disturbance, lack of fear or excessive fearfulness, and depression.

 

 

Symptoms

 

¨     Impaired social interactions: failure to develop age appropriate peer relationships, no desire to seek or share enjoyment or interests with others, lack of social or emotional reciprocity, impairment in the use of nonverbal behaviors

¨     Restrictive Behavior: Repetitive, stereotyped behaviors, interests, and activities, intense focus and preoccupation with things that do not interest others, inflexible adherence to nonfunctional routines or rituals, stereotyped or repetitive mannerisms, preoccupation  with “parts” of objects.

¨     Impaired Communication: Delay in, or total lack of, spoken language; Inability to initiate or sustain conversations with others; idiosyncratic, stereotyped and repetitive language; lack of make believe or social imitative play

 

 

 

 

Medications Commonly Used to Treat Developmental Disorders

 

¨     Antipsychotics

¨     Mood Stabilizers

¨     Stimulants

¨     Antidepressants

 

 

 

Oppositional Defiant Disorder

 

         Prevalence rates of 2-16%. Symptoms usually emerge by age 8 and have a gradual onset. Symptoms occur more often in the home setting and with familiar figures. The disorder is more prevalent in families with harsh, inconsistent, or neglectful childrearing practices, or when there has been a succession of different caregivers. More common in males than females before puberty; rates equal after puberty. Males tend to have more confrontational behavior and persistent symptoms. Males who have problematic temperaments and high motoric activity in preschool are at higher risk. Most children do not see themselves as oppositional, but justify their behavior as a response to unreasonable demands or circumstances.  Four of the following symptoms must be present for 6 months to receive the diagnosis.

 

 

Symptoms

 

¨     Frequently loses temper

¨     Argues with adults (verbal, not physical aggression, is common)

¨     Defies or refuses to comply with adults’ requests or rules

¨     Deliberately annoys others (persistent testing of limits)

¨     Blames others for his/her behaviors

¨     Touchy, easily annoyed by others

¨     Angry and resentful (mood lability, low frustration tolerance)

¨     Spiteful or vindictive

 

 

 

 

Conduct Disorder

 

                 

 

Prevalence rates range from 1-10% and is more common in males than females. Males demonstrate more physical violence and destructive behaviors; females demonstrate more acting out behaviors. Onset is usually during the transition period from mid-childhood to mid-adolescence. Childhood onset type occurs prior to age 10 and has a worse prognosis than adolescent onset type (no symptoms prior to age 10). A substantial proportion continue to show symptoms into adulthood that meet criteria for Antisocial Personality Disorder. Must have at least 1 of the following 4 criteria present during the past 12 months to receive diagnosis.

 

 

 

 

Aggression to People and Animals

 

¨     Often bullies, threatens, or intimidates others

¨     Initiates physical fights

¨     Has used a weapon that can cause harm

¨     Physically cruel to people

¨     Physically cruel to animals

¨     Has confronted a victim while stealing

¨     Forced someone into sexual activity

 

Destruction of Property

 

¨     Intentional fire setting

¨     Deliberately destroys property

 

Deceitfulness or Theft

 

¨     Has broken into a house, car, or building

¨     Cons others

¨     Stealing without confronting a victim

 

Serious Violations of Rules

 

¨     Stays out at night or for long periods of time before age 13

¨     Runs away overnight at least twice

¨     Truancy before age 13

 

 

Medications Used to Treat Disruptive Behavior Disorders

 

¨     Mood stabilizers

¨     Antidepressants

¨     Antipsychotics